56.(氫水)電解還原水能有效減緩長期洗腎病患因透析導致T細胞壞死狀況-原文論文翻譯~

原文論文翻譯

(氫水)電解還原水能有效減緩長期洗腎病患因透析導致T細胞壞死狀況。

本研究來自於台大、陽明醫學院、亞東醫院與日本機構所發表的共同研究，對於末期洗腎病患施予一年期的(氫水)電解水，研究結果發現氫水對於長期洗腎病患，因透析治療造成的T細胞壞死狀況，能有效地減緩T細胞之壞死，增加病患生活之品質。

電解也是製造"氫水"的簡單方式之一，可以產生氫氣，修

補受損之DNA，預防抗氧化

氫水的製備方法可透過1.電解，2.水與礦石反應、3.高壓灌注，選擇任一方法均可備製水中含氫之氫水，任一方法皆可並無特殊性、惟成本與時間之差異。日本、韓國、中國研究中使用之氫水，均因其實驗設計使用三種方式產生氫水，水中含氫氣即為氫水，檢測方法須應用溶氫檢測儀檢測之、只要水中含氫氣即為醫學研究所定義之氫水。

Electrolysed-reduced water (ERW) with rich atomic hydrogen obtained by electrolysis scavenges O2 −• , H2O2 and HOCl and protects DNA, lipids and proteins from oxidative damage

、健康氫水、水素水、負電位、ORP、抗氧化、抗自由基 、氫分子醫學、氫水、Hydrogen water、氫氣、氫、氫水、台灣氫水實驗室、台灣氫水研究中心、氫思語、孫學軍、太田成男、鹼性離子水、小分子水、能量水、電解水、富氫水、負氫水、活水、健康、養生、活力、

Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis

Kuo-Chin Huang^1,*, Shih-Ping Hsu^2,3,*, Chih-Ching Yang^4,5,*, Pu Ou-Yang², Kun-Tai Lee⁶, Shinkatsu Morisawa⁷, Kazumichi Otsubo⁷ and Chiang-Ting Chien²

¹ Department of Family Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan ² Department of Medical Research, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan ³Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan ⁴ Department of Health, Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan ⁵ Department of Internal Medicine, National Yang-Ming University, Taipei, Taiwan ⁶ Wan-Hua Regional Hospital, Taipei, Taiwan ⁷ Nihon-Trim Co., Ltd, Osaka, Japan

Correspondence and offprint requests to: Chiang-Ting Chien; E-mail: ctchien@ntuh.gov.tw

Abstract

Background. T-cell damage by increased oxidative stress in end-stage renal disease (ESRD) patients undergoing chronic haemodialysis (HD) led to the increased T-cell apoptosis and the alteration of surface markers and Th1/Th2 ratio in CD4⁺ T lymphocytes. Antioxidant electrolysed-reduced water (ERW) was used as the dialysate in ESRD patients undergoing chronic HD to test for improved oxidative stress-related T-cell apoptosis, alterations of surface markers and intracellular cytokine profile.

Methods. We evaluated apoptosis formation by annexin V, CD25-related surface markers, and cytokine ratio of Th1/Th2 in CD4⁺ T lymphocytes and Tc1/Tc2 in CD8⁺ T lymphocytes of 42 ESRD patients haemodialysed with ERW for 1 year.

Results. In comparison to 12 healthy individuals, the ESRD patients had more T-cell apoptosis and less CD3⁺, CD4⁺ and CD8⁺ T cells and CD25/CD69/CD94/CD3⁺ phenotypes at baseline. Lower intracellular IL-2 and IFN- levels in the Th1/CD4⁺ and Tc1/CD8⁺ cells andhigher intracellular IL-4, IL-6 and IL-10 levels in the Th2/CD4⁺ and Tc2/CD8⁺ cells were also noted in the ESRD patients. After a 1-year ERW treatment, the patients had a decrease in T-cell apoptosis and increases in CD3⁺, CD4⁺ and CD8⁺ cell numbers and CD25/CD69/CD94/CD3⁺phenotypes in the T cells. The intracellular IL-2 and IFN- levels in the Th1/Tc1 cells significantly (P < 0.05) increased and the intracellular IL-4, IL-6 and IL-10 levels in the Th2/Tc2 cells decreased. Furthermore, the Th1/Th2 and Tc1/Tc2 cytokine ratios were improved toward a normal status.

Conclusion. One-year ERW treatment effectively ameliorated T-cell apoptosis, altered CD25-related surface markers and intracellular cytokine profile in the HD patients.

Keywords: apoptosis; electrolysed reduced water; end-stage renal disease; oxidative stress; T-lymphocyte

^* These authors contributed equally to this work.

原文摘要出處：

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