24.氫水對順鉑腎臟毒的治療作之研究 #MRI #氫水

氫水對順鉑腎臟毒的治療作用：MRI研究

Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging

過去日本學者先後採用一般病理學和生物化學手段，CT等手段證明氫水能治療經典化學治療藥物順鉑腎臟毒。現在他們又採用MRI的方法證明了同樣的作用。

     注意他們採用的MRI是的BOLD加權，就是血紅蛋白水準依賴的信號，這個信號過去比較經典的用途是研究腦功能，本質是測定血流的變化。因為當血流下降或升高後，局部靜脈血的血氧含量相對發生改變，這種變化可以用MRI進行顯示。研究通過對腎臟的功能，組織學，動物體重的進行了檢測。全部都支援氫氣對這個疾病的治療作用。

Hydrogen-rich water sealed in a 200-ml aluminum pouch (I’rom Pharmaceutical, Tokyo, Japan) was used. The concentrations of dissolved hydrogen in hydrogen-rich water and standard water were 1.2 ± 0.1 mg/l (mean ± SD) and 0.06 ± 0.01 mg/l, respectively, as measured using a dissolved hydrogen analyzer (DH-35A; DKKTOA, Tokyo, Japan). When feeding, HW from the aluminum pouch was placed into a closed glass vessel. To minimize the loss of hydrogen while feeding, the lid of the glass vessel was equipped with a metal tube containing two ball bearings. The vessels containing the HW given to the rats were freshly prepared twice a da

研究中使用鋁箔袋保存溶氫水，並且低溫至於玻璃密閉容器中，控制最少的氫氣散失。

研究使用1.2 ± 0.1 mg/l =1.2ppm 1200ppb 濃度之溶氫水。 

Jpn J Radiol. 2011 Aug;29(7):503-12. Epub 2011 Sep 1.

Investigation of protective effect of hydrogen-rich water against cisplatininduced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging.

Matsushita T, Kusakabe Y, Kitamura A, Okada S, Murase K.

Source

Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Abstract

PURPOSE:

The aim of this study was to assess the mechanism of the protective effect of hydrogen-rich water (HW) against cisplatin (CP)-induced nephrotoxicity in rats using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).

MATERIALS AND METHODS:

Apparent transverse relaxation time-weighted images (T2*WI) were acquired in 28 rats. The control group (n = 7) had free access to standard water (SW) and no CP injection. The CP group (n = 7) had free access to SW and was given a CP injection on day 0. The CP+HW group (n = 7) had free access to HW and had a CP injection. The HW group (n = 7) had free access to HW and no CP injection. The apparent transverse relaxation rate (R2*) was estimated from T2*WI.

RESULTS:

In the CP+HW group, the R2* value in the medulla normalized by the value of the day 0 was significantly greater than that in the CP group on days 4 and 7. The creatinine and blood urea nitrogen levels in the CP group were significantly higher than those in the control, CP+HW, and HW groups.

CONCLUSION:

BOLD MRI may be useful for demonstrating the change in R2* in CP-induced nephrotoxicity in rats. The changes in the CP+HW group were suspected to be due to a reduction of cytotoxic oxygen radicals.

PMID:21882093 [PubMed - in process]

原文http://blog.sciencenet.cn/home.php?mod=attachment&id=9858

引用文獻：http://blog.sciencenet.cn/blog-41174-483726.html  

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