69.氫氣治療慢性阻塞性肺損傷#COPD

這是我的一個學生寫的一個觀點類文章。2011年發表，不過這類研究目前已經有許多。氫氣在許多疾病中都有研究，但過去慢性阻塞性肺損傷仍未見報道，從疾病類型上考慮，肺的炎症損傷是一大類重要疾病。考慮到氫氣在炎症方面的重要保護作用，應該考慮針對該類疾病的探討。目前關於氫氣保護肺部損傷的研究已經有一些報導，例如最早關於小腸缺血後肺損傷，後來有氧氣誘導慢性肺損傷、百草枯誘導的肺損傷以及肺移植後的缺血再灌注損傷。

大量研究表明，氫氣通過特異性清除羥自由基和亞硝酸陰離子，可治療各種氧化損傷。氫氣能有效減少脂質和核酸過氧化，提高細胞抗氧化能力，從而保護細胞對抗氧化損傷。人體內許多自由基屬於活性氧，包括超氧陰離子、羥自由基和亞硝酸陰離子等等。正常環境下，細胞在一些酶和抗氧化物質的協助下，可在活性氧的產生和清除之間保持動態穩定。但是在病理情況下，這種平衡被打破，導致氧化應激和各種疾病，慢性阻塞性肺損傷就是一種典型的氧化損傷類疾病。研究表明，活性氧在慢性阻塞性肺損傷的病理生理過程中具有關鍵作用，一些抗氧化物質能有效治療該類疾病。因此我們認為，氫氣可能具有治療該疾病的作用。

點評：該論文發表後，已經有數篇論文證明氫氣呼吸或飲用氫水對COPD的治療作用。空氣污染尤其是霧霾引起的人類疾病，最主要的應該是肺部疾病，雖然無法肯定氫氣能減少霧霾導致的肺損傷，但從理論上推測，氫氣應該能作為減少空氣污染導致肺部疾病的預防措施，甚至作為空氣污染導致各種疾病的預防手段。

Abstract http://www.frontiersin.org/pharmacology_of_natural_products/abstract/9062

The protective effect of hydrogen (H2) on ROS-induced diseases has been proved by many researches, which demonstrated that through eliminating •OH and •ONOO-, H2 could effectively attenuate lipid and DNA peroxidation, improve cellular antioxidant capacity, and then protect cells against oxidant damage. Most of free radicals in human body are ROS, including O2•-, •OH, H2O2, NO•, •ONOO- and so on. Under normal circumstances cells are able to maintain an adequate homeostasis between the formation and removal of ROS through particular enzymatic pathways or antioxidants. But under some pathological conditions, the balance is disturbed, leading to oxidative stress and various diseases, such as COPD (chronic obstructive pulmonary disease). Studies have shown that ROS played a pivotal role in the development of COPD and some antioxidants were effective in the protection against the damaging effects of oxidative stress. Therefore, we hypothesize that owing to its peculiarity to eliminate toxic ROS, hydrogen therapy may be a novel and effective treatment for COPD.

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